Correlation between Plasma Malondialdehyde and Ceruloplasmin Activity in Patients with Malignant Haematological Diseases

The plasma level of ceruloplasmin (Cp) as an antioxidant protein in patients suffering from different malignant haematological diseases was studied. Significantly higher level of Cp was detected in malignant haemopathies (p<0.001) in comparison to the controls. Lipid peroxidation (MDA) as a marker of oxidative stress in the plasma of patients with malignant haemopathies was also increased in comparison with healthy volunteers (p<0.05). Moreover, a positive correlation was observed between the levels of plasma Cp and MDA in patients with malignant haemopathies (R=0.407, p=0.74) but not in the controls. After polychemotherapy, the oxidative stress significantly progressed and appeared to be compromised by augmented activity of ceruloplasmin in these patients.